Kelly Brook"s ultimatum to a bruised Danny Cipriani after pub crawl bus smash

'Sort your life out or it's over': Kelly Brook's ultimatum to a bruised Danny Cipriani after pub crawl bus smash

By
Emily Sheridan and Lucy Buckland

PUBLISHED:

00:58 GMT, 28 April 2013

|

UPDATED:

08:56 GMT, 28 April 2013

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Model Kelly Brook has reportedly given Danny Cipriani an ultimatum after the rugby champ was hit by a bus on a pub crawl.

Celebrity Juice star Kelly, 33, is thought to be worried about her boyfriends drunken antics and has issued him with an ultimatum – 'sort your life out, or it's over.'

The pair, who rekindled their romance in February, were seen looked stony faced as they headed out over the weekend with Danny, 25, on crutches with bruises covering his face.

Crocked: Danny Cipriani hobbles out of his girlfriend Kelly Brook's London home on Friday night

Crocked: Danny Cipriani hobbles out of his girlfriend Kelly Brook's London home on Friday night

A close friend told the Sunday Mirror:
'Kelly has told Danny that that he needs to sort himself out if their
relationship is going to work.

'Kelly feels quite protective over him
and is always wanting to look after him. But her friends are warning
her she could get hurt.'

Kelly, who was reunited with Danny in London on Thursday when he was discharged from hospital, looked concerned as she followed her boyfriend to a taxi on Friday evening.

Supportive: Kelly was no doubt playing nurse to her injured boyfriend after he was discharged on Thursday

Supportive: Kelly was no doubt playing nurse to her injured boyfriend after he was discharged on Thursday

Earlier that day, he took to Twitter
to thanks friends and fans for their get well messages and admitted he
was 'very lucky indeed' to have survived the accident.

He tweeted: 'Can count myself very lucky #dazedandconfused.

'Count myself v lucky…

'Find out about my knee later/monday.'

He also paid tribute to the emergency services who had rushed to his aide.

Battered: The 25-year-old leaving Leeds General Infirmary on Thursday

Battered: The 25-year-old leaving Leeds General Infirmary on Thursday

He wrote: 'Big thank you to the paramedics doctors nurses and Kylie the policewoman – made a scary situation go smoothly #tramnights.'

Danny was knocked down by a double-decker bus during a pub crawl in Leeds on Wednesday night.

On Thursday, he was photographed looking battered and bruised as he hobbled out of Leeds General Infirmary, with several deep grazes on his face.

Danny also appeared to have bruises on his left arm, which could just be seen underneath his tattoo sleeve.

Scare: Danny lying on a stretcher being attended to by paramedics on Wednesday night

Scare: Danny lying on a stretcher being attended to by paramedics on Wednesday night

Despite the accident, which
potentially could have been fatal, Danny has retained his sense of
humour, and tweeted after leaving hospital: 'My ribs are a bit sore…
Feel like I've been hit by a bus.'

Danny
was lucky not to have been injured further in the accident, which
occurred following the 14-bar pub crawl with his rugby teammates.

A
picture from the scene shows Danny strapped to a stretcher, attended to
by paramedics and Yorkshire police, as the windscreen of the number 6
bus is completely smashed in.

Witnesses said they saw the group 'running around drunkenly in the road' just before the smash at 20.39pm on Wednesday evening, with one adding: 'Every bit of the bus front window is smashed to pieces, imagine what the guy looks like.'

Danny's manager James added: 'It was a group social, I don't think you can single out Danny for certain behaviour. I haven't spoken to him yet but he is at home recovering and is a bit shaken up.'

Women using so much Botox it"s stopped working: Users develop antibodies making treatment less effective

Women using so much Botox it's stopped working: Users develop antibodies making treatment less effective

By
Tanith Carey and Stephen Adams

PUBLISHED:

00:11 GMT, 28 April 2013

|

UPDATED:

00:12 GMT, 28 April 2013

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The Botox industry in the UK is worth an estimated 18million a year

The Botox industry in the UK is worth an estimated 18million a year, with patients paying up to 200 a time for one injection

It is the 200-a-time beauty treatment many women swear by to smooth out their wrinkled foreheads and crow’s feet.

But those relying on Botox to hold back the years could be wasting their money – because they are becoming immune to the injections, warn scientists.

They say the drug, a type of neurotoxin, is failing to freeze the facial muscles of some patients as well as it did before, or for as long.

Many women are even developing antibodies to some types of the treatment, meaning it stops working altogether.

A review by German researchers, published in the Journal of Neural Transmission, found that one in 200 Botox users developed antibodies, making the treatment less effective over time.

Patients who needed larger doses – including those prescribed it for medical reasons to treat spasms or sweating – were more likely to stop responding, the research found.

Other scientists, writing in the British Medical Journal’s online forum Open, revealed that repeated injections ‘can trigger an immune response… which might lead to non-responsiveness to treatment’.

Dr Kuldeep Minocha, of Harley Street’s Absolute Aesthetics Clinic, who specialises in facial injections, said that he had noticed some patients beginning to develop immunity to the treatment.

‘With people who have been using Botox for ten years or so, you can start to see a bit more resistance,’ he added.

‘The results can wear out a bit quicker
because their body seems to get used to it and recognises it as a
foreign body, and breaks it down quicker.’

He
also pointed out that while the numbers developing antibodies against
the procedure remain small, the true figures could be much higher
because so few patients were tested when their treatment failed to
work.

The toxins effectively paralysies the muscles

The toxin the effects of which last for around four months works by stopping the chemical reactions in muscles that make them naturally contract, effectively paralysing them

Abhilash Jain, a consultant plastic surgeon and medical lecturer at Oxford University, said many patients using Botox had no idea that they could become immune to it.

‘I inform my patients they may not always get the same result following each injection because there are other factors that contribute to this,’ he added.

‘I also tell them about the small risk of antibody formation as part of the counselling process that I do.’

Although it is not known why some patients become unresponsive to the injections, doctors say it could be down to the way the treatment is administered.

Dr David Eccleston, of the MediZen Clinic in Birmingham, who trains others how to use Botox, said some unscrupulous clinics could be diluting it with too much saline solution to make supplies go further.

Patients could also be receiving the wrong dose, rendering it ineffective.

Dr Nick Lowe, a consultant dermatologist at the Cranley Clinic in London, added: ‘There are multiple reasons why patients may become resistant.

‘It’s similar to the way people become resistant to antibiotics. It may be due to any number of different mechanics by which the toxin works within the cells.’

The Botox industry in the UK is worth an estimated 18 million a year, with patients paying up to 200 a time for one injection.

The toxin – the effects of which last for around four months – works by stopping the chemical reactions in muscles that make them naturally contract, effectively paralysing them.

Although many different brands are used in cosmetic procedures, the best-known is Botox, which is made by the US firm Allergan.

An Allergan spokesman said: ‘It is possible, albeit rare, for resistance to develop to any of the botulinum toxins.’

A gentle giant who died on a jog: The 6ft3in schoolboy aged 14 who collapsed on a run yards from his home

A gentle giant who died jogging: Healthy 6ft 3in schoolboy, 14, collapsed yards from his home while training for charity run

By
Sadie Nicholas

PUBLISHED:

21:00 GMT, 27 April 2013

|

UPDATED:

22:08 GMT, 27 April 2013

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Tragedy: Joe Humphries, 14, died of Sudden Arrhythmic Death Syndrome (SADS) while out jogging

Tragedy: Joe Humphries, 14, died of Sudden Arrhythmic Death Syndrome (SADS) while out jogging

Like millions of others, schoolboy Joe Humphries watched TV in horror when Bolton Wanderers midfielder Fabrice Muamba collapsed after suffering a cardiac arrest during a cup tie against Tottenham Hotspur last year.

Less than seven months later, 14-year-old Joe also suffered a cardiac arrest while out running near his home in Rothley, Leicestershire.

Unlike for Fabrice, there was no heart specialist nearby who could dash to his rescue.

Though passers-by fought hard to save his life and paramedics arrived within minutes of a 999 call, Joe was pronounced dead that night at Leicester Royal Infirmary.

His parents, Angela and Steve, were later told that their fit, healthy son – already a strapping 6ft 3in ‘gentle giant’ – had died from Sudden Arrhythmic Death Syndrome.

One of the first to hear the news was former England rugby captain and coach Martin Johnson, who has known Steve for 20 years. Johnson was so shaken by the tragedy that he agreed to become a patron of the Joe Humphries Memorial Trust, which was launched last month by Steve, Angela and a group of friends.

Its purpose is to help raise awareness of the risk factors associated with SADS, and highlight how lives can be saved if someone does collapse, as Joe did on October 4 last year.

‘Joe came home from school, had his tea, then went out at 6.30pm for a jog with his friend Meg, with whom he was doing a charity run the following weekend,’ says Angela, a biomedical scientist at Leicester Royal Infirmary.

‘I’d just got back from the supermarket when a neighbour knocked on the door and said something had happened. Steve ran down the road and as I stood at the front door I heard an ambulance – Steve missed it by minutes as it sped off with Joe in the back.

‘When we got to the hospital, they were still working on Joe. We weren’t allowed to see him until it was all over.’

Martin
Johnson says: ‘People are told SADS is rare, but it’s not that rare if
it’s happening to more than 600 people a year, is it’

Support: Martin Johnson, pictured in 2011, is a patron of the Joe Humphries Memorial Trust, which was launched last month to raise awareness of Sudden Arrhythmic Death Syndrome

Support: Ex England Rugby captain Martin Johnson, pictured in 2011, is a patron of the Joe Humphries Memorial Trust, which was launched last month to raise awareness of Sudden Arrhythmic Death Syndrome

In the event that a person does collapse, cardiopulmonary resuscitation (CPR) can be the difference between life and death.

Now Joe’s classmates at De Lisle College in Loughborough have filmed a video with Johnson explaining CPR and how to use a defibrillator – a device that delivers an electric shock to the heart to try to restart it. The footage is available online.

‘If CPR is started within eight minutes, the majority of cases could be saved,’ says Dr Ffion Davies, who is calling for more defibrillators to be located in areas where there are large numbers of people or where sport takes place regularly.

Steve adds: ‘We can’t get Joe back but the trust is his legacy. I won’t rest until we’ve done everything in our power to try to prevent other families going through the hell that we’ll take with us to our own graves.’

Visit the Joe Humphries Memorial Trust at jhmt.org.uk.

Bernie: Oddball comedy drama is trying something different that"s not quite working

Oddball comedy drama Bernie is trying something different that's not quite working

By
Chris Tookey

PUBLISHED:

00:42 GMT, 26 April 2013

|

UPDATED:

12:25 GMT, 26 April 2013

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Bernie (12A)

Verdict: Oddball comedy-drama

U.S. writer-director Richard Linklater has made a weird little biopic about a real-life, small-town mortician and murderer, well loved in his local community of Carthage, Texas.

The role is embraced by Jack Black, who is on good, if muted, form. He makes Bernie a well-intentioned, churchgoing innocent, cruelly exploited by the affluent widow (Shirley MacLaine) he was eventually accused of slaughtering.

The reason this is a curious film is that it’s interspersed by mockumentary footage of locals (played by actors but often quoting real witnesses) enthusing about Bernie. Little sympathy is extended towards his victim.

Scroll down for video

Jack Black doesn't quite make it all the way as Bernie

Jack Black doesn't quite make it all the way as Bernie

One resident even comes out with the justification: ‘It’s not as bad as people say — he only shot her four times, not five.’

The story is too one-paced and monotonous to capture a big audience, and falls midway between comedy and drama, but Black gives his most nuanced performance in years.

I didn’t find it very entertaining, but it is at least trying something different.

User: Jack Black's Bernie takes advantage of lonely Shirley MacLaine's affluent widow

User: Jack Black's Bernie takes advantage of lonely Shirley MacLaine's affluent widow

Weird biopic: Jack Black embraces role

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Denise Van Outen heads out armed with an overnight bag amid rumours of marriage trouble with Lee Mead

Going somewhere Stony-faced Denise Van Outen heads out with an overnight bag amid rumours of marriage trouble with Lee Mead

By
Kelby Mcnally

PUBLISHED:

16:55 GMT, 26 April 2013

|

UPDATED:

18:10 GMT, 26 April 2013

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Despite all the rumours that her marriage to Lee Mead is on the rocks over the past couple of months, Denise Van Outen has rarely been spotted without a smile on her face.

But it looks as though the strain is finally getting to the TV star after she stepped out of her house armed with an overnight bag on Friday.

The 38-year-old failed to raise any sort of smile as she headed out of her north London home, speculating that things might not be all rosy in the star's marriage.

Going somewhere Denise emerges from her North London home with an overnight bag

Going somewhere Denise emerges from her North London home with an overnight bag

The former Strictly contestant wore dark sunglasses as she clambered into the back of the car, without even a glimpse of her husband.

Denise kept her outfit plain in black jeans and a slogan jumper, completing her outfit with a cropped leather jacket.

Speculation has been mounting as the couple have not been seen together for some time, and Denise even revealed in an interview they were leading very separate lives.

The star has been battling troubled marriage rumours for the past couple of months

The star has been battling troubled marriage rumours for the past couple of months

The star has been battling troubled marriage rumours for the past couple of months

She admitted she hasn't spent much time with West End star Lee, 31, who has been going back and forward to Los Angeles for auditions.

She told Now magazine: 'To be honest, it is really difficult. We just haven't seen each other.

'I started on Strictly in September and we've been like passing ships in the night. I'm not going to lie, it's been a massive strain on the relationship.'

The former Strictly star admitted that it has been the 'hardest few months'

The former Strictly star admitted that it has been the 'hardest few months'

Denise and her husband Lee Mead haven't been seen together for some time, speculating that the pair have split

Denise and her husband Lee Mead haven't been seen together for some time, speculating that the pair have split

Denise – who takes turns in looking after their two-year-old daughter Betsy while Lee is at work – admitted that the past few months have been hard.

'We haven't really spent any proper time together for six months…' she said.

'I'd say this has been the hardest few months out of all our time together.'

Denise and Lee mark their fourth wedding anniversary this month, with daughter Betsy turning three next month.

The couple famously met on BBC talent show Any Dream Will Do in 2007, but didn't go public until months after the show ended.

Trouble in paradise Denise and Lee, who have a daughter together, celebrate their fourth wedding anniversary this month

Trouble in paradise Denise and Lee, who have a daughter together, celebrate their fourth wedding anniversary this month

Daniel Radcliffe sparks concern with his gaunt and exhausted appearance

What happened to Harry Potter Daniel Radcliffe sparks concern with his gaunt and exhausted appearance

By
Daily Mail Reporter

PUBLISHED:

13:38 GMT, 26 April 2013

|

UPDATED:

14:12 GMT, 26 April 2013

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He was once the fresh-faced young actor who hit the big time when he was cast as teenage wizard Harry Potter.

But Daniel Radcliffe has certainly come a long way from Hogwarts, judging by his exhausted and gaunt appearance as he stepped out in London on Friday morning.

The 23-year-old actor looked ghostly pale with dark circles around his eyes as he arrived at the BBC Radio 2 studios for an interview with Chris Evans at just after 8am.

Exhausted: Daniel Radcliffe sparked concern with his gaunt and tired appearance as he arrived at the BBC Radio 2 studios in London early on Friday morning

Exhausted: Daniel Radcliffe sparked concern with his gaunt and tired appearance as he arrived at the BBC Radio 2 studios in London early on Friday morning

Transformation: Daniel has come a long way from Hogwarts - with dark circles around his eyes and an incredibly pale complexion

Transformation: Daniel has come a long way from Hogwarts - with dark circles around his eyes and an incredibly pale complexion

Transformation: Daniel has come a long way from Hogwarts – with dark circles around his eyes and an incredibly pale complexion

Wearing an open-neck checked shirt,
with a grey blazer and cord trousers, Daniel took time to sign
autographs for fans outside the studios before heading inside.

But fans could be forgiven for
getting concerned about the way Daniel looked, with the actor looking unshaven and dishevelled for the outing.

The British actor revealed previously how he had to give up drinking after becoming too reliant on alcohol, but is regularly photographed smoking cigarettes.

Since starring in the Harry Potter
franchise, Daniel has been concentrating more on his theatre career, and
can soon be seen in upcoming play The Cripple Of Inishmaan.

Dishevelled: Daniel wore an open-neck checked shirt and went unshaven for the outing

Dishevelled: Daniel wore an open-neck checked shirt and went unshaven for the outing

Meeting the fans: Daniel took the time to meet fans and sign autographs ahead of going in for the interview

Meeting the fans: Daniel took the time to meet fans and sign autographs ahead of going in for the interview

Speaking about starting rehearsals for the production on Monday, Daniel told Evans: 'It's
quite nerve wracking – meeting everybody for the first time. Apart from
me and a couple of other people, most of the cast is Irish.

'So for the non-Irish members of the
cast, we will be thinking about the accent a lot. But I'm looking
forward to meeting everybody and getting started.'

And asked if he has prepared ahead of
the first day of rehearsals, Daniel said: 'I've learnt my lines. Some
actors like to go in and learn it as they go but if I don't do that I
will stress about it. I'm not that kind of a laidback guy, I have to do
the work beforehand.

'It's just about repetition – I just read them over and over again to learn them, and also read them out loud.'

As well as his stage career, Daniel
also had several films coming out over the next few months, including
Kill Your Darlings, in which he stars a poet Allen Ginsberg, and fantasy
drama Horns.

Boy, 8, dies from asthma attack after playing Quaser laser on his birthday

Boy, 8, dies from asthma attack after playing Quaser laser at a birthday party Adam Mark Winfandale's condition 'was very manageable', said motherStaff at local laser game centre deemed him fit enough to playAfter 15 minutes of playing, Adam came out of game and requested inhaler
But he said it didn't work and within in minutes his condition deteriorated

Ambulance arrived within one minute but Adam died in hospital

By
Anna Hodgekiss

PUBLISHED:

09:53 GMT, 26 April 2013

|

UPDATED:

14:34 GMT, 26 April 2013

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An eight-year-old boy collapsed and died after an asthma attack at a friend's birthday party, an inquest heard.

Adam Mark Winfandale, who used two inhalers to manage the illness, was rushed to hospital on June 5, 2011 and was pronounced dead on arrival.

He was having fun with pals at a Quasar laser quest event in Chester when he suffered breathing difficulties.

An inquest jury at Warrington Town Hall heard yesterday how Adam's mother, Susan Jones, said despite his asthma he was a healthy boy who enjoyed tennis, swimming lessons and doing activities with the Cubs and Scouts.

Tragedy: Adam Winfandale collapsed and died after an asthma attack at a friend's birthday party

Tragedy: Adam Winfandale collapsed and died after an asthma attack at a friend's birthday party

'Adam's asthma was very manageable,' she said. 'We had never had a panic moment. I always had a warning with his asthma, as it was always a slow build up.'

But on Sunday June 5, Adam left his home at Bryn Celyn, Moss, Wrexham, north Wales, to join his friends at Quasar and died after encountering breathing difficulties.

A parent at the party, Janet Ellams, said Miss Jones had explained to her about Adam's asthma and had given his inhaler to her.

'He won't need it, it's just in case,' Miss Jones said. 'He will know when he needs it and how much he can take.'

The children arrived at Quasar at 11am and were given a health and safety briefing where Adam was asked about his asthma and if he was fine to play. Staff deemed he was able to play and the game began.

Ms Ellams said: 'About 15 minutes in Adam came out and said he needed his inhaler. He seemed quite calm when he came out. He was standing against the wall and wanting to get back into the game.'

Miss Jones was called and told Adam had asked for his inhaler and she said her son would know what to do.

But Adam said the inhaler was not working and became distressed and agitated.

The inquest heard that there may have been some particles in the air at Quasar (pictured) which could have been a contributory factor to Adam's asthma attack

The inquest heard that there may have been some particles in the air at Quasar (pictured) which could have been a contributory factor to Adam's asthma attack

The hearing was told Adam's condition worsened in just a matter of minutes. An ambulance was called and Adam was carried outside for more air. Witnesses said he was rigid and his lips and hands were blue.

The ambulance arrived in one minute and Adam was treated immediately en route to the Countess of Chester Hospital.

Miss Jones was called and headed straight to the hospital to see her son but Adam was pronounced dead at the hospital at 3.20pm.

Adam Salmon, co-owner of Quasar, told the hearing the game Adam was playing usually involved smoke, music and lighting.

But on this occasion the liquid smoke machine was not working and had been broken for a couple of weeks.

An inquest jury at Warrington Town Hall heard that despite his asthma, Adam was a healthy boy who enjoyed tennis, swimming lessons and Scouts

An inquest jury at Warrington Town Hall heard that despite his asthma, Adam was a healthy boy who enjoyed tennis, swimming lessons and Scouts

Mr Salmon said there could have been some particles in the air which could have been a contributory factor to Adam's asthma attack.

During the inquest Adam's parents raised concerns about whether Quasar had good health and safety policies in place.

But Helen Stott, lead environmental health practitioner for Cheshire West and Chester Council, said Quasar had followed all health and safety rules and complied with all relevant legislation.

In the week leading up to the party Adam had been on holiday with Miss Jones in Majorca and had no asthma or breathing troubles.

They returned on Saturday, June 4 and Adam was described as being 'very well'.

The inquest, before Cheshire assistant deputy coroner Alan Moore, continues.

Coffee could boost the effect of breast cancer drug tamoxifen

Two cups of coffee a day HALVES the risk of breast cancer returning by boosting the effect of medication
With tamoxifen, coffee could halve the rate of breast cancer recurrence
Tamoxifen works by stopping oestrogen reaching the tumour cells
Oestrogen causes tumour cells to divide meaning that the tumour grows
Researchers don't know why coffee makes the drug more effective

By
Emma Innes

PUBLISHED:

11:42 GMT, 26 April 2013

|

UPDATED:

11:42 GMT, 26 April 2013

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Drinking two cups of coffee a day could stop breast cancer recurring in recovering patients, new research has revealed.

Combined with the anti-cancer drug tamoxifen, coffee could halve the rate of recurrence of breast cancer, scientists have discovered.

Researchers at Lund University in Sweden believe that coffee actually boosts the effect of the drug.

Drinking two cups of coffee a day could stop breast cancer recurring in recovering patients

Drinking two cups of coffee a day could stop breast cancer recurring in recovering patients

They looked at 600 breast cancer patients from southern Sweden over a five year period.

About 300 of them took tamoxifen – a drug commonly prescribed after breast cancer surgery.

Tamoxifen is an anti-oestrogen drug that is widely used to treat breast cancer.

Many breast cancers rely on the female sex hormone oestrogen to grow.

Hormone-positive breast cancer cells have proteins which oestrogen attaches too.

When it comes into contact with these proteins it fits into them and stimulates the cancer cells to divide so that the tumour grows.

Tamoxifen works by fitting into the oestrogen receptors and blocking the hormone from reaching the cancer cells.

This means the tumour either grows more slowly or stops growing altogether.

Combined with the anti-cancer drug tamoxifen, coffee could halve the rate of breast cancer recurrence

Combined with the anti-cancer drug tamoxifen, coffee could halve the rate of breast cancer recurrence

Maria Simonsson, a doctoral student in Oncology at Lund University said: ‘Patients who took the pill, along with two or more cups of coffee daily, reported less than half the rate of cancer recurrence, compared with their non-coffee drinking, tamoxifen-taking counterparts.

‘How coffee interacts with the treatment, however, isn't immediately known.

‘One theory we are working with is that coffee “activates” tamoxifen and makes it more efficient.’

The Lund University researchers have previously linked coffee consumption to a decreased risk of developing certain types of breast cancer.

Caffeine has also been shown to hamper the growth of cancer cells. The latest observational study involving coffee's role in cancer prevention and treatment underlines the need for more research, according to the team.

Helena Jernstrvm, Associate Professor of Experimental Oncology at Lund University added: ‘We would like to know more about how lifestyle can interact with breast cancer treatment.’

This is not the first study to link coffee consumption with improved cancer prognosis.

Scientists at Harvard Medical School have found that women who drink three or more cups of coffee a day have a 20 per cent lower risk of developing the most common form of skin cancer compared to those who had less than one cup per month.

They also found that men who drank the same amount saw a nine per cent lower risk of the skin cancer, basal cell carcinoma.

Taller, skinnier women have evolved to have more babies than their shorter counterparts

Taller, skinnier women have evolved to have more babies than their shorter counterparts
Study found that over past 55 years African women who are tall and lean are having bigger familiesExperts are not sure why this is but believe improvements in healthcare and nutrition play role

By
Rachel Reilly

PUBLISHED:

09:26 GMT, 26 April 2013

|

UPDATED:

11:55 GMT, 26 April 2013

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Trials of HIV vaccine halted after research found it failed to prevent infections

Trials of US HIV vaccine halted after research found it failed to prevent infectionsStudy called HVTN 505 was found not to prevent infection or reduce levels of virus in bloodResearch is just one of many failed attempts to develop a vaccination for disease

By
Rachel Reilly

PUBLISHED:

11:19 GMT, 26 April 2013

|

UPDATED:

11:46 GMT, 26 April 2013

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Research into a new HIV vaccine has been halted after experts found it to be of no use.

The U.S. government stopped trials of the experimental HIV vaccine after an independent review found it did not prevent HIV infection or reduce the amount of HIV in the blood.

The research, started in 2009, it is just the latest in a series of failed attempts to develop a vaccine for the virus.

The study, called HVTN 505, had enrolled 2,504 volunteers in 19 U.S. cities.

Scientists are trying to develop a vaccine for the HIV virus but progress is slow

Scientists are trying to develop a vaccine for the HIV virus but progress is slow

‘This trial has provided a clear, swift answer about a specific vaccine strategy,' Mitchell Warren, executive director of the nonprofit group AVAC: Global Advocacy for HIV Prevention, told Reuters.

It's not the answer we hoped for, but the search doesn't end here.

‘Researchers need to unpack the data from this trial to understand more about why this strategy didn't prevent infection.’

The review board has recommended that no further vaccinations be given. The National Institutes of Allergy and Infectious Disease, which sponsored the study, said it would continue to follow study participants to further evaluate the trial data.

The HVTN 505 trial tested a two-part vaccine strategy designed to first prime the immune system and then provide a vaccine 'boost'.

The vaccine itself was based on a common cold virus that was used to sneak HIV genes into the body and grab the attention of the immune system.

So far, there are no vaccines approved to prevent infection with the human immunodeficiency virus or HIV, the virus that causes AIDS.

Several HIV trials are still underway or in planning stages, including a follow-up to a Thai trial which in 2009 showed a vaccine combination cut HIV infections by 31.2 percent.

Killer: The HIV virus attacks the body's immune system

Killer: The HIV virus attacks the body's immune system

Although the finding was not strong enough to approve the vaccine, it offered the first glimpse that a vaccine could work.

Both of these vaccines – the one in the Thai study and the HVTN 505 study – are largely designed to train immune system cells known as T-cells to recognize and kill cells already infected with HIV.

Researchers are studying other approaches, including vaccines that activate powerful antibodies to prevent HIV from infecting cells in the first place.

Matthew Rose, a vaccine advocate for AVAC who participated in the HVTN 505 study, said he remains hopeful in the search for a vaccine.

'These results do not change the fundamental view that an AIDS vaccine remains critical to any long-term strategy to end the AIDS epidemic,' he said.


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