Women using so much Botox it"s stopped working: Users develop antibodies making treatment less effective

Women using so much Botox it's stopped working: Users develop antibodies making treatment less effective

By
Tanith Carey and Stephen Adams

PUBLISHED:

00:11 GMT, 28 April 2013

|

UPDATED:

00:12 GMT, 28 April 2013

DM.has('shareLink', 'shareLinks',
'id': '2315979',
'title': 'Women using so much Botox it's stopped working: Users develop antibodies making treatment less effective',
'url': 'http://www.dailymail.co.uk/health/article-2315979/Women-using-Botox-stopped-working-Users-develop-antibodies-making-treatment-effective.html',
'eTwitterStatus': 'Women%20using%20so%20much%20Botox%20it's%20stopped%20working:%20Users%20develop%20antibodies%20making%20treatment%20less…%20http://bit.ly/ZVVi2X%20via%20@MailOnline'
);

The Botox industry in the UK is worth an estimated 18million a year

The Botox industry in the UK is worth an estimated 18million a year, with patients paying up to 200 a time for one injection

It is the 200-a-time beauty treatment many women swear by to smooth out their wrinkled foreheads and crow’s feet.

But those relying on Botox to hold back the years could be wasting their money – because they are becoming immune to the injections, warn scientists.

They say the drug, a type of neurotoxin, is failing to freeze the facial muscles of some patients as well as it did before, or for as long.

Many women are even developing antibodies to some types of the treatment, meaning it stops working altogether.

A review by German researchers, published in the Journal of Neural Transmission, found that one in 200 Botox users developed antibodies, making the treatment less effective over time.

Patients who needed larger doses – including those prescribed it for medical reasons to treat spasms or sweating – were more likely to stop responding, the research found.

Other scientists, writing in the British Medical Journal’s online forum Open, revealed that repeated injections ‘can trigger an immune response… which might lead to non-responsiveness to treatment’.

Dr Kuldeep Minocha, of Harley Street’s Absolute Aesthetics Clinic, who specialises in facial injections, said that he had noticed some patients beginning to develop immunity to the treatment.

‘With people who have been using Botox for ten years or so, you can start to see a bit more resistance,’ he added.

‘The results can wear out a bit quicker
because their body seems to get used to it and recognises it as a
foreign body, and breaks it down quicker.’

He
also pointed out that while the numbers developing antibodies against
the procedure remain small, the true figures could be much higher
because so few patients were tested when their treatment failed to
work.

The toxins effectively paralysies the muscles

The toxin the effects of which last for around four months works by stopping the chemical reactions in muscles that make them naturally contract, effectively paralysing them

Abhilash Jain, a consultant plastic surgeon and medical lecturer at Oxford University, said many patients using Botox had no idea that they could become immune to it.

‘I inform my patients they may not always get the same result following each injection because there are other factors that contribute to this,’ he added.

‘I also tell them about the small risk of antibody formation as part of the counselling process that I do.’

Although it is not known why some patients become unresponsive to the injections, doctors say it could be down to the way the treatment is administered.

Dr David Eccleston, of the MediZen Clinic in Birmingham, who trains others how to use Botox, said some unscrupulous clinics could be diluting it with too much saline solution to make supplies go further.

Patients could also be receiving the wrong dose, rendering it ineffective.

Dr Nick Lowe, a consultant dermatologist at the Cranley Clinic in London, added: ‘There are multiple reasons why patients may become resistant.

‘It’s similar to the way people become resistant to antibiotics. It may be due to any number of different mechanics by which the toxin works within the cells.’

The Botox industry in the UK is worth an estimated 18 million a year, with patients paying up to 200 a time for one injection.

The toxin – the effects of which last for around four months – works by stopping the chemical reactions in muscles that make them naturally contract, effectively paralysing them.

Although many different brands are used in cosmetic procedures, the best-known is Botox, which is made by the US firm Allergan.

An Allergan spokesman said: ‘It is possible, albeit rare, for resistance to develop to any of the botulinum toxins.’

A gentle giant who died on a jog: The 6ft3in schoolboy aged 14 who collapsed on a run yards from his home

A gentle giant who died jogging: Healthy 6ft 3in schoolboy, 14, collapsed yards from his home while training for charity run By Sadie Nicholas PUBLISHED: 21:00 GMT, 27 April 2013 | UPDATED: 22:08 GMT, 27 April 2013 DM.has('shareLink', 'shareLinks', { 'id': '2315720', 'title': 'A gentle giant who died jogging: Healthy 6ft 3in schoolboy, 14, collapsed yards from his home while training for charity run', 'url': 'http://www.dailymail.co.uk/health/article-2315720/A-gentle-giant-died-jog-The-6ft3in-schoolboy-aged-14-collapsed-run-yards-home.html', 'eTwitterStatus': 'A%20gentle%20giant%20who%20died%20on%20a%20jog:%20The%206ft3in%20schoolboy%20aged%2014%20who%20collapsed%20on%20a%20run%20yards%20from…%20http://bit.ly/11MoAnk%20via%20@MailOnline' }); Tragedy: Joe Humphries, 14, died of Sudden Arrhythmic Death Syndrome (SADS) while out jogging Like millions of others, schoolboy Joe Humphries watched TV in horror when Bolton Wanderers midfielder Fabrice Muamba collapsed after suffering a cardiac arrest during a cup tie against Tottenham Hotspur last year. Continue reading

Boy, 8, dies from asthma attack after playing Quaser laser on his birthday

Boy, 8, dies from asthma attack after playing Quaser laser at a birthday party Adam Mark Winfandale's condition 'was very manageable', said motherStaff at local laser game centre deemed him fit enough to playAfter 15 minutes of playing, Adam came out of game and requested inhaler But he said it didn't work and within in minutes his condition deteriorated Ambulance arrived within one minute but Adam died in hospital By Anna Hodgekiss PUBLISHED: 09:53 GMT, 26 April 2013 | UPDATED: 14:34 GMT, 26 April 2013 DM.has('shareLink', 'shareLinks', { 'id': '2315117', 'title': 'Boy, 8, dies from asthma attack after playing Quaser laser at a birthday party', 'url': 'http://www.dailymail.co.uk/health/article-2315117/Boy-8-dies-asthma-attack-playing-Quaser-laser-birthday.html', 'eTwitterStatus': 'Boy,%208,%20dies%20from%20asthma%20attack%20after%20playing%20Quaser%20laser%20on%20his%20birthday%20http://bit.ly/15LzsqZ%20via%20@MailOnline' }); An eight-year-old boy collapsed and died after an asthma attack at a friend's birthday party, an inquest heard. Continue reading

Coffee could boost the effect of breast cancer drug tamoxifen

Two cups of coffee a day HALVES the risk of breast cancer returning by boosting the effect of medication With tamoxifen, coffee could halve the rate of breast cancer recurrence Tamoxifen works by stopping oestrogen reaching the tumour cells Oestrogen causes tumour cells to divide meaning that the tumour grows Researchers don't know why coffee makes the drug more effective By Emma Innes PUBLISHED: 11:42 GMT, 26 April 2013 | UPDATED: 11:42 GMT, 26 April 2013 DM.has('shareLink', 'shareLinks', { 'id': '2315186', 'title': 'Two cups of coffee a day HALVES the risk of breast cancer returning by boosting the effect of medication', 'url': 'http://www.dailymail.co.uk/health/article-2315186/Coffee-boost-effect-breast-cancer-drug-tamoxifen.html', 'eTwitterStatus': 'Coffee%20could%20boost%20the%20effect%20of%20breast%20cancer%20drug%20tamoxifen%20http://bit.ly/15LVZUv%20via%20@MailOnline' }); Drinking two cups of coffee a day could stop breast cancer recurring in recovering patients, new research has revealed. Continue reading

Taller, skinnier women have evolved to have more babies than their shorter counterparts

Taller, skinnier women have evolved to have more babies than their shorter counterparts Study found that over past 55 years African women who are tall and lean are having bigger familiesExperts are not sure why this is but believe improvements in healthcare and nutrition play role By Rachel Reilly PUBLISHED: 09:26 GMT, 26 April 2013 | UPDATED: 11:55 GMT, 26 April 2013 DM.has('shareLink', 'shareLinks', { 'id': '2315134', 'title': 'Taller, skinnier women have evolved to have more babies than their shorter counterparts', 'url': 'http://www.dailymail.co.uk/health/article-2315134/Taller-skinnier-women-evolved-babies-shorter-counterparts.html', 'eTwitterStatus': 'Taller,%20skinnier%20women%20have%20evolved%20to%20have%20more%20babies%20than%20their%20shorter%20counterparts%20http://bit.ly/15LHvEg%20via%20@MailOnline' }); Continue reading

Trials of HIV vaccine halted after research found it failed to prevent infections

Trials of US HIV vaccine halted after research found it failed to prevent infectionsStudy called HVTN 505 was found not to prevent infection or reduce levels of virus in bloodResearch is just one of many failed attempts to develop a vaccination for disease By Rachel Reilly PUBLISHED: 11:19 GMT, 26 April 2013 | UPDATED: 11:46 GMT, 26 April 2013 DM.has('shareLink', 'shareLinks', { 'id': '2315175', 'title': 'Trials of US HIV vaccine halted after research found it failed to prevent infections', 'url': 'http://www.dailymail.co.uk/health/article-2315175/Trials-HIV-vaccine-halted-research-failed-prevent-infections.html', 'eTwitterStatus': 'Trials%20of%20HIV%20vaccine%20halted%20after%20research%20found%20it%20failed%20to%20prevent%20infections%20http://bit.ly/13zgnEh%20via%20@MailOnline' }); Research into a new HIV vaccine has been halted after experts found it to be of no use. Continue reading

Being overweight and drinking alcohol TRIPLES the risk of deadly liver disease in women

Being overweight and drinking alcohol TRIPLES the risk of deadly liver disease in womenUK study confirms the dangerous link between drinking alcohol, being overweight and liver diseaseLiver disease is the fifth biggest killer in the UKNumber of people dying from condition has risen by 20 per cent over the past decade By Rachel Reilly PUBLISHED: 13:22 GMT, 26 April 2013 | UPDATED: 14:16 GMT, 26 April 2013 DM.has('shareLink', 'shareLinks', { 'id': '2315236', 'title': 'Being overweight and drinking alcohol TRIPLES the risk of deadly liver disease in women', 'url': 'http://www.dailymail.co.uk/health/article-2315236/Being-overweight-drinking-alcohol-TRIPLES-risk-deadly-liver-disease-women.html', 'eTwitterStatus': 'Being%20overweight%20and%20drinking%20alcohol%20TRIPLES%20the%20risk%20of%20deadly%20liver%20disease%20in%20women%20http://bit.ly/13ztrtg%20via%20@MailOnline' }); Being overweight and drinking alcohol dramatically increases the risk of developing fatty liver disease, according to a study presented at the International Liver Congress. Continue reading

Childbirth experts warn umbilical cords should not be cut for up to FIVE minutes

Childbirth experts warn umbilical cords should not be cut for up to FIVE minutesClamping cord seconds after baby's arrival deprives it of vital bloodExperts say this can lead to iron deficiency and anaemia in later life By Lucy Osborne PUBLISHED: 02:24 GMT, 26 April 2013 | UPDATED: 13:17 GMT, 26 April 2013 DM.has('shareLink', 'shareLinks', { 'id': '2315052', 'title': 'Childbirth experts warn umbilical cords should not be cut for up to FIVE minutes', 'url': 'http://www.dailymail.co.uk/health/article-2315052/Childbirth-experts-warn-umbilical-cords-cut-FIVE-minutes.html', 'eTwitterStatus': 'Childbirth%20experts%20warn%20umbilical%20cords%20should%20not%20be%20cut%20for%20up%20to%20FIVE%20minutes%20http://bit.ly/13zstgy%20via%20@MailOnline' }); Cutting the umbilical cord too early is putting babies' health at risk, childbirth experts have warned. Continue reading

Believing in God can help treat depression

The power of prayer: Believing in God can help treat depressionNew research has found that people who believe in a higher power respond better to psychiatric treatmentBenefit is not confined to a specific religion By Rachel Reilly PUBLISHED: 17:23 GMT, 25 April 2013 | UPDATED: 07:06 GMT, 26 April 2013 A strong faith in a higher power has been shown to improve mental health Belief in God may improve treatment for those suffering with depression, says a new study. Continue reading

Mum and daughter diagnosed with breast cancer on the same day… then have surgery on the same day too!

Mum and daughter diagnosed with breast cancer on the same day… Continue reading